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Cochrane review, for example, looked at six randomized controlled studies (comprising 419 patients) comparing injectable fluphenazine with oral antipsychotics, and found that the depot medication did not reduce relapse more than oral neuroleptics (David A et al, Depot fluphenazine decanoate and enanthate for schizophrenia.

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This medication is a combination of a tricyclic antidepressant (amitriptyline) and an antipsychotic medication (perphenazine).

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Typical ("first-generation") antipsychotics include haloperidol (Haldol), chlorpromazine (Thorazine), perphenazine (Trilafon), thioridazine (Mellaril), trifluoperazine (Stelazine), and fluphenazine (Prolixin).

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Although parental influence is no longer believed to directly lead to the development of schizophrenia, certain types of childhood trauma (including sexual and physical abuse) may play a role.

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They used to be called “depot” antipsychotics, but the powers that be have renamed them “long acting injectables” (LAIs), presumably to help remove some of the stigma associated with their use.

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