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We thank the study participants and their parents, the Mile High Down Syndrome Association, the Denver Adult Down Syndrome Clinic and the Colorado Springs Down Syndrome Association for their help with participant recruitment.

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C) renal, gynecological, musculoskeletal, neurological, gastrointestinal, metabolic, hematological, endocrine, cancer with a metastatic potential or progressive neurological disorders) which could impair reliable participation in the trial or necessitate the use of medication not allowed by this protocol.

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