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Our clinical question is: in paediatric patients, is combined or alternating antipyretic treatment more effective than monotherapy for reducing discomfort and temperature in the first 24 to 48 hours of acute febrile illness?

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The greatest risk for severe liver injury happens when people take more than the prescribed dose of acetaminophen, take more than one acetaminophen-containing product at the same time, or drink alcohol while taking acetaminophen.

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In addition, the effectiveness of administering combined or alternating antipyretics may be very different when administered by parents and caregivers than when administered in a controlled setting with health care professionals supervising.

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Attention à ne pas dépasser cette dose (lire sous intoxication en bas de page).

Discomfort' is not an easily definable outcome and this review was only able to consider a few measurable, albeit potentially indirect, manifestations (ie pain score, amount of medication given, days away from daycare).

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Compared to giving a single antipyretic alone, giving combined paracetamol and ibuprofen to febrile children can result in a lower mean temperature at one hour after treatment ( moderate quality evidence).

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In the next five years, the study found no difference between the groups in blood pressure control or kidney function.

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Heubi 1998 conducted a study looking at 47 case reports of overdose with therapeutic intent and found a mortality rate of 55%, with half of the deaths in children less than two years old and 52% of cases receiving adult preparations of paracetamol ().

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