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This study was conducted in the paediatric inpatient services of two hospitals in Beirut: the American University of Beirut Medical Centre (AUBMC), which is a tertiary care facility; and Najjar Hospital, a secondary care facility.

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Electrochemical determination of acetaminophen (APAP) was successfully performed using a carbon paste electrode (CPE) modified with coffee husks (CH-CPE).

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Given the widespread use of paracetamol, the fact that it is metabolized by the liver, and the occurrence of asymptomatic transaminasemia, it is easy to understand the questions regarding administration of paracetamol to patients with a liver compromised for any reason.

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Our clinical question is: in paediatric patients, is combined or alternating antipyretic treatment more effective than monotherapy for reducing discomfort and temperature in the first 24 to 48 hours of acute febrile illness?

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The greatest risk for severe liver injury happens when people take more than the prescribed dose of acetaminophen, take more than one acetaminophen-containing product at the same time, or drink alcohol while taking acetaminophen.

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In addition, the effectiveness of administering combined or alternating antipyretics may be very different when administered by parents and caregivers than when administered in a controlled setting with health care professionals supervising.

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Attention à ne pas dépasser cette dose (lire sous intoxication en bas de page).

Discomfort' is not an easily definable outcome and this review was only able to consider a few measurable, albeit potentially indirect, manifestations (ie pain score, amount of medication given, days away from daycare).

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Compared to giving a single antipyretic alone, giving combined paracetamol and ibuprofen to febrile children can result in a lower mean temperature at one hour after treatment ( moderate quality evidence).

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In the next five years, the study found no difference between the groups in blood pressure control or kidney function.

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Acetaminophen, unlike other common analgesics such as aspirin and ibuprofen, has no anti-inflammatory properties or effects on platelet function, and so it is not a member of the class of drugs known as non-steroidal anti-inflammatory drugs or NSAIDs.

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Heubi 1998 conducted a study looking at 47 case reports of overdose with therapeutic intent and found a mortality rate of 55%, with half of the deaths in children less than two years old and 52% of cases receiving adult preparations of paracetamol ().

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