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In six patients who were seropositive for HIV, the clearance of zidovudine (100 mg q 8 h) was decreased by 38% after administration of valproate (250 or 500 mg q 8 h); the half-life of zidovudine was unaffected.

It is merely one more factor of application, alternative symptomatic treatment vs.

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Valproate-induced acute liver failure and liver-related deaths have been reported in patients with hereditary neurometabolic syndromes caused by mutations in the gene for mitochondrial DNA polymerase γ (POLG) (e.

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Table 3 summarizes those adverse reactions reported for patients in these trials where the incidence rate in the divalproex sodium extended-release tablets-treated group was greater than 5% and greater than the placebo incidence.

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